Discovery and development of anti-angiogenic peptides: A structural link

• Published in: Angiogenesis (London) Vol. 6; no. 2; pp. 83 - 91
• Main Authors: DINGS, Ruud P. M, NESMELOVA, Irina, GRIFFIOEN, Arjan W, MAYO, Kevin H
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 2003; Springer Nature B.V
• Subjects: Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - metabolism; Angiogenesis Inhibitors - therapeutic use; Animals; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Drug Design; Endothelial Cells - metabolism; Humans; Medical sciences; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - metabolism; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Peptide Fragments - therapeutic use; Peptides - chemistry; Peptides - metabolism; Peptides - therapeutic use; Structure-Activity Relationship; Angiogenesis; Cardiovascular disease; Treatment; Malignant tumor; Fragment; Structure function relationship
• ISSN: 0969-6970; 1573-7209
• DOI: 10.1023/B:AGEN.0000011730.94233.06

Cancer is a disease promoted by excess angiogenesis. Interference with this process poses an attractive approach to controlling aberrant tumor growth, a hypothesis first proposed in the early 1970s that led to world-wide focus on identifying and developing angiogenesis inhibitors, which currently number in the hundreds. This review surveys the discovery and development of anti-angiogenic protein fragments and peptides, with a slant towards understanding their structure-function relationships to aid in the design of better therapeutic agents.