An enzyme-free DNA walker that moves on the surface of functionalized magnetic microparticles and its biosensing analysis

An enzyme-free stochastic DNA walker propelled by a single catalytic or double catalytic DNA assembly has been constructed. The application of the proposed DNA walking biosensor was successfully expanded to the detection of DNA and the enzymatic activity of T4 polynucleotide kinase.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 53; no. 60; pp. 8486 - 8488
Main Authors Li, Ningxing, Zheng, Jiao, Li, Chunrong, Wang, Xinxin, Ji, Xinghu, He, Zhike
Format Journal Article
LanguageEnglish
Published England 25.07.2017
Subjects
Bacteriophage T4 - enzymology
Biosensing Techniques
DNA - analysis
DNA, Catalytic - chemistry
DNA, Catalytic - metabolism
Magnetite Nanoparticles - chemistry
Polynucleotide 5'-Hydroxyl-Kinase - metabolism
Surface Properties
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Summary:An enzyme-free stochastic DNA walker propelled by a single catalytic or double catalytic DNA assembly has been constructed. The application of the proposed DNA walking biosensor was successfully expanded to the detection of DNA and the enzymatic activity of T4 polynucleotide kinase.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc04547f