Radiomics model of diffusion-weighted whole-body imaging with background signal suppression (DWIBS) for predicting axillary lymph node status in breast cancer

• Published in: Journal of X-ray science and technology Vol. 31; no. 3; pp. 627 - 640
• Main Authors: Haraguchi, Takafumi, Kobayashi, Yasuyuki, Hirahara, Daisuke, Kobayashi, Tatsuaki, Takaya, Eichi, Nagai, Mariko Takishita, Tomita, Hayato, Okamoto, Jun, Kanemaki, Yoshihide, Tsugawa, Koichiro
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: Breast Neoplasms - pathology; Diffusion Magnetic Resonance Imaging - methods; Female; Humans; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Lymphatic Metastasis - diagnostic imaging; Lymphatic Metastasis - pathology; Retrospective Studies; Whole Body Imaging; DWIBS; radiomics; Diffusion-weighted whole-body imaging; breast cancer; axillary lymph node status; machine learning; background signal suppression
• ISSN: 0895-3996; 1095-9114
• DOI: 10.3233/XST-230009

In breast cancer diagnosis and treatment, non-invasive prediction of axillary lymph node (ALN) metastasis can help avoid complications related to sentinel lymph node biopsy. This study aims to develop and evaluate machine learning models using radiomics features extracted from diffusion-weighted whole-body imaging with background signal suppression (DWIBS) examination for predicting the ALN status. A total of 100 patients with histologically proven, invasive, clinically N0 breast cancer who underwent DWIBS examination consisting of short tau inversion recovery (STIR) and DWIBS sequences before surgery were enrolled. Radiomic features were calculated using segmented primary lesions in DWIBS and STIR sequences and were divided into training (n = 75) and test (n = 25) datasets based on the examination date. Using the training dataset, optimal feature selection was performed using the least absolute shrinkage and selection operator algorithm, and the logistic regression model and support vector machine (SVM) classifier model were constructed with DWIBS, STIR, or a combination of DWIBS and STIR sequences to predict ALN status. Receiver operating characteristic curves were used to assess the prediction performance of radiomics models. For the test dataset, the logistic regression model using DWIBS, STIR, and a combination of both sequences yielded an area under the curve (AUC) of 0.765 (95% confidence interval: 0.548-0.982), 0.801 (0.597-1.000), and 0.779 (0.567-0.992), respectively, whereas the SVM classifier model using DWIBS, STIR, and a combination of both sequences yielded an AUC of 0.765 (0.548-0.982), 0.757 (0.538-0.977), and 0.779 (0.567-0.992), respectively. Use of machine learning models incorporating with the quantitative radiomic features derived from the DWIBS and STIR sequences can potentially predict ALN status.