Alkyl-aryl ketone synthesis via nickel-catalyzed reductive coupling of alkyl halides with aryl acids and anhydrides

The present work disclosed a considerably improved method for the construction of alkyl-aryl ketones by the direct coupling of unactivated alkyl bromides with 1.5 equiv. of acids. In addition, the synthesis of aroyl C-glycosides was first achieved by the reductive coupling of 1-glycosyl bromides wit...

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Published inChemical communications (Cambridge, England) Vol. 51; no. 51; pp. 10302 - 10305
Main Authors Jia, Xiao, Zhang, Xinghua, Qian, Qun, Gong, Hegui
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.06.2015
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
REAGENTS
ACYL CHLORIDES
ACYLATION
ALLYLATION
ORGANIC HALIDES
THIOL ESTERS
BROMIDES
CYCLIZATION
CARBOXYLIC-ACIDS
COBALT
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Summary:The present work disclosed a considerably improved method for the construction of alkyl-aryl ketones by the direct coupling of unactivated alkyl bromides with 1.5 equiv. of acids. In addition, the synthesis of aroyl C-glycosides was first achieved by the reductive coupling of 1-glycosyl bromides with acid derivatives, which may otherwise require multi-step synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc03113c