Associations between hsa-miR-603 polymorphism, lifestyle-related factors and colorectal cancer risk

• Published in: Cancer biomarkers : section A of Disease markers Vol. 14; no. 4; pp. 225 - 231
• Main Authors: Wang, Fen-Juan, Ding, Ye, Mao, Ying-Ying, Jing, Fang-Yuan, Zhang, Zhen-Yu, Jiang, Long-Fang, Guo, Jian-Feng, Sun, Xiang-Jue, Jin, Ming-Juan, Chen, Kun
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2014
• Subjects: Case-Control Studies; China - epidemiology; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Female; Genotype; Humans; Life Style; Male; MicroRNAs - genetics; Middle Aged; Polymorphism, Single Nucleotide; China; polymorphism; colorectal cancer; susceptibility; hsa-miR-603
• ISSN: 1574-0153; 1875-8592
• DOI: 10.3233/CBM-140395

Accumulated studies have suggested that single nucleotide polymorphisms (SNPs) in microRNAs are associated with risk of colorectal cancer (CRC). We tested our hypothesis that rs11014002 in hsa-miR-603 may be associated with CRC risk with a crosstalk of life-related factors. We conducted a case-control study which included 102 CRC patients and 204 matched cancer-free controls in Xiaoshan County. We observed that subjects with rs11014002 CT/TT genotype had an increased susceptibility for CRC (CT vs. CC: odds ratio (OR)=2.352, 95% confidence interval (CI): 1.142-4.840, P=0.020; CT+TT vs. CC: OR=2.031, 95% CI: 1.063-3.883, P=0.032). After stratification by lifestyle-related factors, similar results were found among nonsmokers (CT vs. CC: OR=2.753, 95% CI: 1.085-6.983, P=0.033; CT+TT vs. CC: OR=2.971, 95% CI: 1.188-7.435, P=0.020) and non-alcohol drinkers (CT+TT vs. CC: OR=3.279, 95% CI: 1.071-10.033, P=0.037). Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility.