A dimethoxytriazine type glycosyl donor enables a facile chemo-enzymatic route toward alpha-linked N-acetylglucosaminyl-galactose disaccharide unit from gastric mucin

An efficient chemo-enzymatic process for construction of the alpha-linked disaccharide unit (GlcNAc alpha 1-4Gal) found in gastric mucin has been developed. The process consists of a one-step preparation of a novel triazine type glycosyl donor in water and the subsequent transglycosylation to a gala...

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Published inChemical communications (Cambridge, England) Vol. 48; no. 45; pp. 5560 - 5562
Main Authors Noguchi, Masato, Nakamura, Miwa, Ohno, Ayaka, Tanaka, Tomonari, Kobayashi, Atsushi, Ishihara, Masaki, Fujita, Masaya, Tsuchida, Akiko, Mizuno, Mamoru, Shoda, Shin-ichiro
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.06.2012
Subjects
Acetylglucosaminidase - metabolism
Bacteroides - enzymology
Chemistry
Chemistry, Multidisciplinary
Disaccharides - chemical synthesis
Disaccharides - chemistry
Disaccharides - metabolism
Galactose - analogs & derivatives
Galactose - chemical synthesis
Galactose - metabolism
Gastric Mucins - chemical synthesis
Gastric Mucins - chemistry
Gastric Mucins - metabolism
Physical Sciences
Science & Technology
Triazines - chemistry
Triazines - metabolism
OLIGOSACCHARIDE SYNTHESIS
SUGARS
CHLORIDE
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Summary:An efficient chemo-enzymatic process for construction of the alpha-linked disaccharide unit (GlcNAc alpha 1-4Gal) found in gastric mucin has been developed. The process consists of a one-step preparation of a novel triazine type glycosyl donor in water and the subsequent transglycosylation to a galactose derivative catalysed by alpha-N-acetylglucosaminidase.
Bibliography:KAKEN
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc30946g