Bruton’s tyrosine kinase regulates B cell antigen receptor-mediated JNK1 response through Rac1 and phospholipase C-γ2 activation
Bruton’s tyrosine kinase (Btk) is essential for B cell development and B cell antigen receptor (BCR) function. Recent studies have shown that Btk plays an important role in BCR-mediated c-Jun NH 2-terminal kinase (JNK) 1 activation; however, the mechanism by which Btk participates in the JNK1 respon...
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Published in | FEBS letters Vol. 514; no. 2; pp. 260 - 262 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
13.03.2002
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Subjects | |
Online Access | Get full text |
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Summary: | Bruton’s tyrosine kinase (Btk) is essential for B cell development and B cell antigen receptor (BCR) function. Recent studies have shown that Btk plays an important role in BCR-mediated c-Jun NH
2-terminal kinase (JNK) 1 activation; however, the mechanism by which Btk participates in the JNK1 response remains elusive. Here we show that the BCR-mediated Rac1 activation is significantly inhibited by loss of Btk, while this Rac1 activation is not affected by loss of phospholipase C-γ2 (PLC-γ2). Since PLC-γ2 is also required for BCR-mediated JNK1 response, our results suggest that Btk regulates Rac1 pathway as well as PLC-γ2 pathway, both of which contribute to the BCR-mediated JNK1 response. |
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ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/S0014-5793(02)02375-X |