Antiulcer effect of Helminthostachys zeylanica (L.) Hook. root extract on ethanol-induced acute gastric lesion in Wistar rats

Context: Helminthostachys zeylanica is well known as a traditional medicine with various pharmacological activities, including antioxidant and anti-inflammatory. These activities are needed in the treatment of gastric ulcers. Aims: To evaluate the effectiveness of H. zeylanica as an antiulcer agent...

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Published inJournal of pharmacy & pharmacognosy research Vol. 10; no. 3; pp. 508 - 516
Main Authors Fitrya, Fitrya, Amriani, Annisa, Novita, Rennie Puspa, Pamela, Friscilla Nindita
Format Journal Article
LanguageEnglish
Published GarVal Editorial Ltda 01.05.2022
Subjects
gastric ulcer
helminthostachys zeylanica
ulcer index
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Summary:Context: Helminthostachys zeylanica is well known as a traditional medicine with various pharmacological activities, including antioxidant and anti-inflammatory. These activities are needed in the treatment of gastric ulcers. Aims: To evaluate the effectiveness of H. zeylanica as an antiulcer agent on acute peptic ulcer. Methods: The antiulcer effect of the H. zeylanica ethanolic extract (100, 200 and 400 mg/kg BW) was studied through ulcer index, physicochemical properties of gastric juice and histopathological analysis in male Wistar rats. Results: The extract reduces ulcer index, gastric fluid volume, total acidity and increases gastric protection factors such as pH and mucus levels. These results were not significantly different from omeprazole (p>0.05). Photomicrograph analysis showed improvement of membrane structure in extract-treated animals. Conclusions: H. zeylanica extract could be valued as an antiulcer agent.
ISSN:0719-4250
0719-4250
DOI:10.56499/jppres21.1336_10.3.508