Anatomical outcomes 1 year after pelvic organ prolapse surgery in patients with and without a uterus at a high risk of recurrence: a randomised controlled trial comparing laparoscopic sacrocolpopexy/cervicopexy and anterior vaginal mesh

• Published in: International Urogynecology Journal Vol. 30; no. 4; pp. 545 - 555
• Main Authors: Bataller, Eduardo, Ros, Cristina, Anglès, Sonia, Gallego, Miriam, Espuña-Pons, Montserrat, Carmona, Francisco
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2019; Springer Nature B.V
• Subjects: Aged; Cervix Uteri - surgery; Dyspareunia - etiology; Female; Follow-Up Studies; Gynecologic Surgical Procedures - adverse effects; Gynecologic Surgical Procedures - methods; Gynecology; Humans; Laparoscopy; Laparoscopy - adverse effects; Laparoscopy - instrumentation; Medicine; Medicine & Public Health; Middle Aged; Operative Time; Organ Size; Original Article; Pelvic organ prolapse; Pelvic Organ Prolapse - pathology; Pelvic Organ Prolapse - surgery; Recurrence; Sacrum - surgery; Severity of Illness Index; Surgery; Surgical Mesh; Treatment Outcome; Urinary Incontinence, Stress - etiology; Urology; Uterus; Vagina - pathology; Vagina - surgery; Laparoscopic sacral colpopexy/cervicopexy; Pelvic organ prolapse; Prolapse recurrence; Anterior vaginal mesh; Mesh surgery
• ISSN: 0937-3462; 1433-3023
• DOI: 10.1007/s00192-018-3702-7

Introduction and hypothesis Few studies have compared the different approaches of mesh surgery in patients with severe pelvic organ prolapse (POP). In addition to laparoscopic sacrocolpopexy/cervicopexy (LSC-Cx), anterior vaginal mesh (AVM) may be an effective approach for correcting anterior vaginal wall associated with apical POP in women with advanced POP. Methods A randomised controlled trial (RCT; January 2011 to March 2016) including 120 patients (60/group) with advanced symptomatic POP, with a predominant anterior vaginal wall descent stage III or greater in combination with a stage II or III apical defect (uterus or vaginal vault). Patients underwent four visits: baseline, 3, 6 and12 months after surgery. The main outcome was anatomical success defined as anterior and posterior vaginal wall not descending beyond the hymen and vaginal apex descent no more than one third into the vagina. Secondary variables: PFDI, ICIQ-UI-SF, intraoperative variables, postoperative morbidity and complications. Results Anatomical success was achieved with LSC-Cx in 79% and with AVM in 76% (NS). No statistically significant differences were found among POP-Q anterior vaginal wall points between groups, whereas better results were obtained with LSC-Cx in posterior vaginal wall points and total vaginal length. Intraoperative outcomes were similar in the two groups, except for operating time (78.05 min LSC-Cx vs 44.28 min AVM). There were no statistically significant differences related to de novo stress urinary incontinence and dyspareunia. Worse results were found in the CRADI-8 in the LSC-Cx group, owing to constipation. Late postoperative complications and reinterventions were similar in the two groups. Conclusions No differences were found in the anatomical correction of anterior and apical POP. The LSC-Cx group presented better correction of posterior vaginal wall defects and a longer total vaginal length.