Sex steroids in women with liver cirrhosis

Eighteen women with hepatic cirrhosis were examined for plasma levels of testosterone, estrone, estradiol, progesterone and sex hormone binding globulin. For eight who were amenorrheic, with advanced liver cirrhosis and ascites, the reduction of testosterone and rise in estrone and sex hormone bindi...

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Bibliographic Details
Published inInternational journal of gynecology and obstetrics Vol. 18; no. 3; p. 181
Main Authors Shaaban, M M, Ghaneimah, S A, Hammad, W A, El-Sharkawy, M M, Elwan, S I, Ahmed, Y A
Format Journal Article
LanguageEnglish
Published United States 1980
Subjects
Adolescent
Adult
Amenorrhea - blood
Amenorrhea - complications
Estradiol
Estrone - blood
Female
Gonadal Steroid Hormones - blood
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Middle Aged
Progesterone - blood
Sex Hormone-Binding Globulin - analysis
Testosterone - blood
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Summary:Eighteen women with hepatic cirrhosis were examined for plasma levels of testosterone, estrone, estradiol, progesterone and sex hormone binding globulin. For eight who were amenorrheic, with advanced liver cirrhosis and ascites, the reduction of testosterone and rise in estrone and sex hormone binding globulin concentrations were significant. Plasma extradiol and progesterone were lower than normal levels, but the differences were not statistically significant. The other ten patients were menstruating (mostly irregularly), and their hormonal levels were assessed in different states of their cycles. All of them did not ovulate, had low levels of plasma progesterone and also showed consistent estrone concentration excess relative to estradiol and significant lowering of testosterone and elevation of sex hormone binding globulin. These findings are compared with previous reports on males with liver cirrhosis.
ISSN:0020-7292
DOI:10.1002/j.1879-3479.1980.tb00276.x