Condensins and 3D Organization of the Interphase Nucleus

Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins ar...

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Bibliographic Details
Published inCurrent genetic medicine reports Vol. 1; no. 4; pp. 219 - 229
Main Authors Wallace, Heather A., Bosco, Giovanni
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.12.2013
Subjects
Genomics (SM Williams
Internal Medicine
Medicine
Medicine & Public Health
Section Editor
Chromosome condensation
SMC proteins
Chromatin
Interphase chromosome
Condensin
Nuclear organization
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Summary:Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins are involved in chromatin organization, gene expression, and DNA repair and indicates similarities between the interphase and mitotic functions of condensin. Recent work has enhanced our knowledge of how chromatin architecture is dynamically regulated by condensin to impact essential cellular processes.
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ISSN:2167-4876
2167-4876
DOI:10.1007/s40142-013-0024-4