Leucocyte migration inhibition in diphtheria toxoid hypersensitivity

A donor who was highly reactive to diphtheria toxoid (DT) in delayed hypersensitivity and in lymphocyte transformation showed scant evidence of antigen-induced inhibition in the direct leucocyte migration agarose test. Other donors, weak or negative to DT in skin test and transformation, did show ev...

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Bibliographic Details
Published inAllergy (Copenhagen) Vol. 42; no. 6; p. 473
Main Authors Saxby, M F, Salaman, M R, Sargent, I L
Format Journal Article
LanguageEnglish
Published Denmark 01.08.1987
Subjects
Adult
Cell Migration Inhibition
Diphtheria Toxoid - adverse effects
Diphtheria Toxoid - immunology
Humans
Hypersensitivity, Delayed - etiology
Hypersensitivity, Delayed - immunology
Leukocyte Migration-Inhibitory Factors - biosynthesis
Leukocytes - immunology
Lymphocyte Activation
Male
Tuberculin Test
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Summary:A donor who was highly reactive to diphtheria toxoid (DT) in delayed hypersensitivity and in lymphocyte transformation showed scant evidence of antigen-induced inhibition in the direct leucocyte migration agarose test. Other donors, weak or negative to DT in skin test and transformation, did show evidence of inhibition. Although the migration test is useful in assessing cellular reactivity to tubercular antigen, these results question its suitability for DT.
ISSN:0105-4538
DOI:10.1111/j.1398-9995.1987.tb00366.x