High-signal-intensity MR Image in the Hepatobiliary Phase Predicts Long-term Survival in Patients With Hepatocellular Carcinoma

• Published in: Anticancer research Vol. 39; no. 8; pp. 4219 - 4225
• Main Authors: Ariizumi, Shun-Ichi, Ban, Daisuke, Abe, Yuta, Kumamoto, Takafumi, Koizumi, Satoshi, Tanabe, Minoru, Shinoda, Masahiro, Endo, Itaru, Otsubo, Takehito, Yamamoto, Masakazu
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.08.2019
• Subjects: Hepatocellular carcinoma; Liver cancer; Magnetic resonance imaging; Medical imaging; Multivariate analysis; Surgery; Survival; Hepatocellular carcinoma; surgical outcome; high-signal-intensity; Gd-EOB-DTPA-enhanced MRI
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.13583

The aim of the study was to evaluate surgical outcomes of patients with high-signal intensity (SI) image hepatocellular carcinoma (HCC). Between 2008 and 2013, 257 HCC patients were retrospectively evaluated. A total of 21 patients were diagnosed as high-SI image HCC, 215 as low-SI image HCC, and 21 patients as mixed (high and low)-SI image HCC in the hepatobiliary (HB) phase of MRI. Five-year overall survival (OS) and recurrence-free survival (RFS) were compared among patient groups. The 5-year OS and RFS rates were significantly higher in patients with high-SI image HCC (100% and 56%) than in patients with low-SI image HCC (71%; p=0.097 and 38%; p=0.0209) and in patients with mixed-SI image HCC (73%; p=0.0329 and 9%; p=0.0021). High-SI image was an independent prognostic factor for OS (relative risk 0.167, p=0.0178) and RFS (relative risk 0.471, p=0.0322) on multivariate analysis. Patients with high-SI image HCC showed favorable long-term survival after curative surgery.