Corynebacterium species nasopharyngeal carriage in asymptomatic individuals aged ≥ 65 years in Germany

• Published in: Infection Vol. 45; no. 5; pp. 607 - 611
• Main Authors: Teutsch, Barbara, Berger, Anja, Marosevic, Durdica, Schönberger, Katharina, Lâm, Thiên-Trí, Hubert, Kerstin, Beer, Steffi, Wienert, Peter, Ackermann, Nikolaus, Claus, Heike, Drayß, Maria, Thiel, Kathrin, van der Linden, Mark, Vogel, Ulrich, Sing, Andreas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2017; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Antibodies; Carrier State - epidemiology; Carrier State - microbiology; Colonization; Corynebacterium; Corynebacterium - isolation & purification; Corynebacterium diphtheriae - isolation & purification; Corynebacterium Infections - epidemiology; Corynebacterium Infections - microbiology; Corynebacterium pseudotuberculosis - isolation & purification; Diphtheria; Diphtheria toxin; Family Medicine; Female; General Practice; Geriatrics; Germany - epidemiology; Humans; Immunity; Immunoglobulins; Infectious Diseases; Internal Medicine; Male; Medicine; Medicine & Public Health; Nasopharyngeal Diseases - epidemiology; Nasopharyngeal Diseases - microbiology; Nasopharynx; Nasopharynx - microbiology; Nose; Older people; Original Paper; Pharynx; Pseudotuberculosis; Retirement; Species; Toxins; Germany; Nasopharyngeal carriage; Diphtheria; species; Age; Anti-diphtheria toxin antibodies; Corynebacterium species
• ISSN: 0300-8126; 1439-0973; 1439-0973
• DOI: 10.1007/s15010-017-1017-0

Purpose The prevalence of protective anti-diphtheria toxin antibodies decreases with age. Therefore, the elderly might serve as reservoir for potentially toxigenic Corynebacterium ( C .) species ( C. diphtheriae, C. ulcerans , and C. pseudotuberculosis) . This study aimed to examine the colonization rate of the nasopharynx with corynebacteria of individuals aged 65 years and older. Methods In the period from October 2012 to June 2013, nasal and throat swabs were taken from 714 asymptomatic subjects aged 65–106 years (average age 77.2) at three regions in Germany and investigated for Corynebacterium species. Results A total of 402 strains of Corynebacterium species were isolated from 388 out of 714 asymptomatic subjects (carriage rate 54.3%). The carriage rate was significantly higher in study participants living in retirement homes (68.4%) compared to those living autonomously at home (51.1%). Strains were isolated mostly from the nose (99%). Corynebacterium accolens was the most often isolated species (39.8%), followed by C. propinquum (24.1%), C. pseudodiphtheriticum (19.4%), and C. tuberculostearicum (10.2%). No C. diphtheriae, C. ulcerans, and C. pseudotuberculosis strains were isolated. A subsample of 74 subjects was tested serologically for anti-diphtheria antibodies. Protective anti-diphtheria toxin antibodies were found in 29.7% of the subjects; 70.3% showed no protective immunity. Conclusions These results suggest that carriage of potentially toxigenic corynebacteria is very rare among people aged 65 and older in Germany. However, the low prevalence of protective anti-diphtheria toxin antibodies might pose a risk for acquiring diphtheria especially for the elderly.