N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

• Published in: Organic & biomolecular chemistry Vol. 9; no. 7; pp. 2069 - 2071
• Main Authors: Kim, Sun Min, Jin, Ming Yu, Kim, Mi Jin, Cui, Yan, Kim, Young Sug, Zhang, Liqiu, Song, Choong Eui, Ryu, Do Hyun, Yang, Jung Woon
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 07.04.2011
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; KETONES; ENANTIOSELECTIVE SYNTHESIS; MANNICH REACTIONS; ALDOL REACTION; QUATERNARY STEREOCENTERS; HYDROBENZOFURANONES; ALDEHYDES; SALTS

A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate t...