N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate t...

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Published inOrganic & biomolecular chemistry Vol. 9; no. 7; pp. 2069 - 2071
Main Authors Kim, Sun Min, Jin, Ming Yu, Kim, Mi Jin, Cui, Yan, Kim, Young Sug, Zhang, Liqiu, Song, Choong Eui, Ryu, Do Hyun, Yang, Jung Woon
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.04.2011
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
KETONES
ENANTIOSELECTIVE SYNTHESIS
MANNICH REACTIONS
ALDOL REACTION
QUATERNARY STEREOCENTERS
HYDROBENZOFURANONES
ALDEHYDES
SALTS
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Summary:A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate to good enantioselectivities for the corresponding Stetter products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/c0ob01178a