A facile approach to highly functional trisubstituted furans via intramolecular Wittig reactions

An efficient and mild synthesis of trisubstituted furans, starting from alpha,beta-unsaturated ketones, tributylphosphine, and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to install the crucial furan ring, leading to a wide variety of highly fu...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 9; no. 7; pp. 2098 - 2106
Main Authors Chen, Ko-Wei, Syu, Siang-en, Jang, Yeong-Jiunn, Lin, Wenwei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.04.2011
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
NUCLEOPHILES
2-(1-ALKYNYL)-2-ALKEN-1-ONES
HETEROCYCLES
TETRASUBSTITUTED FURANS
POLYSUBSTITUTED FURANS
MODULAR ENTRY
ALLENYL KETONES
SUBSTITUTED FURANS
CYCLIZATION
REGIOCONTROLLED SYNTHESIS
Online AccessGet full text

Cover

More Information
Summary:An efficient and mild synthesis of trisubstituted furans, starting from alpha,beta-unsaturated ketones, tributylphosphine, and acyl chlorides, is described. The strategy employs the intramolecular Wittig protocol as a key step to install the crucial furan ring, leading to a wide variety of highly functional furans in one step.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/c0ob00912a