3D modeling for TM receptors: Algorithms and validations

SummaryThis paper outlines the basic strategy to build 3D models of transmembrane G-protein coupled receptors (GPCRs) starting from their amino acid sequences in a ‘block-by-block’ manner: (i) locate possible TM helical fragments in the GPCR sequence; (ii) build 3D structures for these helices; (iii...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of peptide research and therapeutics Vol. 5; no. 5-6; pp. 413 - 415
Main Authors Nikiforovich, Gregory V., Galaktionov, Stan, Tseitin, Vladimir M., Lowis, David R., Shenderovich, Mark D., Marshall, Garland R.
Format Journal Article
LanguageEnglish
Published Leiden Springer Nature B.V 01.10.1998
Subjects
Algorithms
G protein-coupled receptors
Online AccessGet full text

Cover

More Information
Summary:SummaryThis paper outlines the basic strategy to build 3D models of transmembrane G-protein coupled receptors (GPCRs) starting from their amino acid sequences in a ‘block-by-block’ manner: (i) locate possible TM helical fragments in the GPCR sequence; (ii) build 3D structures for these helices; (iii) arrange isolated helices across the membrane; (iv) calculate all pairwise helix-helix interactions; (v) assemble helical bundle(s); (vi) restore interhelical loops and N- and C-termini; and (vii) refine the entire 3D structure(s). Computer algorithms and preliminary results for most of the steps are discussed.
ISSN:0929-5666
1573-3149
1573-496X
1573-3904
DOI:10.1007/BF02443497