A simple sequential one-pot synthesis of 4-aryl thiazole-based Schiff bases

Thiazole based Schiff base scaffolds in recent years have become the integral part of the drug development. These scaffolds are gaining much importance due to their widespread uses as versatile building blocks for the construction of lead drug molecules. Their excellent biological activities have en...

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Bibliographic Details
Published inSynthetic communications Vol. 54; no. 2; pp. 111 - 120
Main Authors Dhanapal, Preethi, Manju, S. L.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis 17.01.2024
Taylor & Francis Ltd
Subjects
4-Aryl thiazoles
Aromatic compounds
Chemistry
Chemistry, Organic
Imines
milder condition
Physical Sciences
Scaffolds
Schiff base
Science & Technology
thiazole
Schiff base
milder condition
4-Aryl thiazoles
thiazole
2-AMINO-4-ARYLTHIAZOLE
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Summary:Thiazole based Schiff base scaffolds in recent years have become the integral part of the drug development. These scaffolds are gaining much importance due to their widespread uses as versatile building blocks for the construction of lead drug molecules. Their excellent biological activities have encouraged us to prepare newer compounds with aryl group in the fourth position of thiazoles incorporating azomethine linkages. The strategies so far reported to obtain 4-aryl thiazoles are time consuming, tedious, and costly. In this context, we report a facile one pot synthetic method to obtain novel 4-aryl thiazoles with excellent yield (83-98%), lesser reaction time (40 min) and under milder conditions with no catalyst and no purification techniques.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2023.2282591