Novel alpha-arylnitriles synthesis via Ni-catalyzed cross-coupling of alpha-bromonitriles with arylboronic acids under mild conditions

An applicable and easy-handling Ni-catalyst can be used to promote direct arylation of alpha-bromonitriles with various arylboronic acids to construct alpha-arylnitriles under mild conditions. The methodology tolerates beta-hydrogens and functional groups in the substrates.

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 9; no. 15; pp. 5343 - 5345
Main Authors Yang, Yingying, Tang, Shan, Liu, Chao, Zhang, Huimin, Sun, Zhexun, Lei, Aiwen
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.08.2011
Subjects
Boronic Acids - chemistry
Bromus - chemistry
Catalysis
Chemistry
Chemistry, Organic
Molecular Structure
Nickel - chemistry
Nitriles - chemical synthesis
Nitriles - chemistry
Physical Sciences
Science & Technology
NITRILES
ARYL HALIDES
ARYLATION
COMPLEXES
BONDS
METAL
LIGAND
ALKYL-HALIDES
VERAPAMIL
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Summary:An applicable and easy-handling Ni-catalyst can be used to promote direct arylation of alpha-bromonitriles with various arylboronic acids to construct alpha-arylnitriles under mild conditions. The methodology tolerates beta-hydrogens and functional groups in the substrates.
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ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob05326d