Indium mediated allylation in peptide and protein functionalization

Indium-mediated allylation has been used in the site-selective functionalization of N-terminal aldehydes of peptides and proteins. This is the first demonstration of indium-mediated C-C bond formation in protein labelling studies under mild and environmentally friendly conditions.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 32; pp. 9066 - 9068
Main Authors Alam, Jenefer, Keller, Thomas H., Loh, Teck-Peng
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.08.2011
Subjects
Aldehydes - chemistry
Allyl Compounds - chemistry
Chemistry
Chemistry, Multidisciplinary
Indium - chemistry
Peptides - chemistry
Physical Sciences
Proteins - chemistry
Science & Technology
CHEMISTRY
N-TERMINAL SERINE
UNNATURAL AMINO-ACIDS
METATHESIS
COMPLEXES
AQUEOUS-SOLUTION
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Summary:Indium-mediated allylation has been used in the site-selective functionalization of N-terminal aldehydes of peptides and proteins. This is the first demonstration of indium-mediated C-C bond formation in protein labelling studies under mild and environmentally friendly conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc12926k