Anti-inflammatory activity of a new compound from Vernonia amygdalina

In this study, a new stigmastane, vernonioside V, was isolated from the ethanol extract of leaves of Vernonia amygdalina along with a known flavonoid, cynaroside, and then anti-inflammatory activity of isolated compounds was investigated. The result showed that vernonioside V at concentration of 30 ...

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Published inNatural product research Vol. 35; no. 23; pp. 5160 - 5165
Main Authors Nguyen, Thi Xuan Thu, Dang, Duc Long, Ngo, Van Quang, Trinh, Tat Cuong, Trinh, Quang Nam, Do, Trung Dong, Thanh, Thi Thu Thuy
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 02.12.2021
Taylor & Francis Ltd
Subjects
anti-inflammatory activity
Anti-inflammatory agents
Cytokines
Ethanol
Flavonoids
Inflammation
Interleukin 6
Interleukin 8
Lipopolysaccharides
Reactive oxygen species
Tumor necrosis factor-α
Vernonia amygdalina
vernonioside V
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Summary:In this study, a new stigmastane, vernonioside V, was isolated from the ethanol extract of leaves of Vernonia amygdalina along with a known flavonoid, cynaroside, and then anti-inflammatory activity of isolated compounds was investigated. The result showed that vernonioside V at concentration of 30 µg/mL strongly inhibited TNFα, IL-6, and IL-8 inflammatory cytokine production. Furthermore, LPS-induced supreoxide generation in Raw 264.7 were significantly reduced by pre-treatment of vernonioside V (30 µg/mL). These data indicated that vernonioside V had inhibitory activities on pro-inflammatory cytokine in LPS-stimulated Raw 264.7 through reactive oxygen species (ROS).
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1788556