Parameters of Humoral and Cellular Immunity to Influenza A/USSR/90/77 (H1N1) Virus in Various Age Groups
After a local epidemic of A/USSR influenza, immunologic parameters related to influenza A/USSR/90/77 (HINl) virus were studied in four age groups: elderly persons (⩾64 years), healthy adults (20–44 years), children (six to 13 years), and neonates (who served as controls). Sera from the first three g...
Saved in:
Published in | The Journal of infectious diseases Vol. 142; no. 5; pp. 699 - 703 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
The University of Chicago Press
01.11.1980
University of Chicago Press |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | After a local epidemic of A/USSR influenza, immunologic parameters related to influenza A/USSR/90/77 (HINl) virus were studied in four age groups: elderly persons (⩾64 years), healthy adults (20–44 years), children (six to 13 years), and neonates (who served as controls). Sera from the first three groups had nearly equivalent titers of hemagglutination-inhibiting antibody (geometric mean titers, 1:8–1:11), which were greater than those in cord blood of neonates. Lymphocyte proliferation responses to influenza A/USSR viral antigens among study groups were similar, with mean stimulation ratios (to whole virus) of 4.2–5.4; neonatal cord blood samples were unresponsive (stimulation ratio, 1.1). In contrast, the magnitude of antibody-dependent cellular cytotoxicity against baby hamster kidney target cells infected with influenza A/USSR virus was significantly greater with lymphocytes from adults and elderly persons (P < 0.05) than with those from children. |
---|---|
Bibliography: | Please address requests for reprints to Dr. Frederick L. Ruben, Montefiore Hospital, 3459 Fifth Avenue, Pittsburgh, Pennsylvania 15213. istex:95A1A90602852BDBDAE43682EBA96D2EC99B5626 ark:/67375/HXZ-0X5HGDDQ-K |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/142.5.699 |