New peperomin and polyketides from dichloromethane extract of Peperomia blanda Jack. (Kunth)

Much of the new research and investigation in pharmacy sciences are concerned with developing therapeutic agents, and identifying and finding new drugs with their chemical structure to treat different human diseases such as infectious diseases from natural products. Therefore, the present findings r...

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Bibliographic Details
Published inTropical biomedicine Vol. 40; no. 4; p. 486
Main Authors Al-Madhagi, W M, Sharhan, O, Jadan, B, Hashim, N M, Awadh, N, Othman, R
Format Journal Article
LanguageEnglish
Published Malaysia 01.12.2023
Subjects
Biological Products
Humans
Methylene Chloride
Peperomia - chemistry
Plant Extracts - pharmacology
Polyketides - chemistry
Polyketides - pharmacology
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Summary:Much of the new research and investigation in pharmacy sciences are concerned with developing therapeutic agents, and identifying and finding new drugs with their chemical structure to treat different human diseases such as infectious diseases from natural products. Therefore, the present findings relate to isolating five new compounds the dichloromethane extract of Peperomia blanda (Jacq.) Kunth grown on Socotra Island, Yemen. two new secolignans; which have been proposed as peperomin I & J. These compounds were isolated together with the other two polyketides presented as surinone D and dindygulerione F. The chemical structures were elucidated and confirmed with nuclear magnetic resonance (NMR) and liquid chromatography-mass spectroscopy (LCMS) analysis. These compounds were first isolated and reported from this plant. These new compounds' antimicrobial activity has been evaluated, and minimum inhibitory concentration has been recorded in the range of 125-250 µg/mL. The pharmacotherapeutic spectrum of compounds was predicated using PASS software which showed potential activity.
ISSN:2521-9855
DOI:10.47665/tb.40.4.015