Supplemental Nocturnal Oxygen in Obstructive Lung Disease

To the Editor: Elimination of order effects and blinding of patients to a change in intervention are important design elements of self-controlled clinical studies. 1 Unfortunately, a recent study of the effect of breathing supplemental nocturnal oxygen on arterial carbon dioxide tensions in patients...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 311; no. 2; p. 128
Main Authors Dyer, E L, Bernard, G R
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 12.07.1984
Subjects
Clinical Trials as Topic
Humans
Lung Diseases, Obstructive - therapy
Oxygen Inhalation Therapy
Research Design
Online AccessGet full text

Cover

More Information
Summary:To the Editor: Elimination of order effects and blinding of patients to a change in intervention are important design elements of self-controlled clinical studies. 1 Unfortunately, a recent study of the effect of breathing supplemental nocturnal oxygen on arterial carbon dioxide tensions in patients with severe chronic obstructive lung disease did not include these elements. 2 In that study each of 15 patients was evaluated in a sleep laboratory on two successive nights. During the first night each patient was studied while breathing supplemental oxygen by nasal cannula. During the second night each patient was studied while breathing room air. The effects . . . No extract is available for articles shorter than 400 words.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Feature-1
ObjectType-Correspondence-3
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198407123110219