Cerebrospinal fluid and serum creatine kinase BB activity after out-of-hospital cardiac arrest

In patients resuscitated from out-of-hospital cardiac arrest, neurologic outcome was compared with creatine kinase isoenzyme BB activity (CKBB) in cerebrospinal fluid (CSF) in 20 patients and in serum in 52 patients. CSF CKBB was 2 units per liter or less in patients with complete neurologic recover...

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Bibliographic Details
Published inNeurology Vol. 31; no. 4; p. 455
Main Authors Longstreth, Jr, W T, Clayson, K J, Sumi, S M
Format Journal Article
LanguageEnglish
Published United States 01.04.1981
Subjects
Brain Injuries - enzymology
Brain Ischemia - enzymology
Creatine Kinase - blood
Creatine Kinase - cerebrospinal fluid
Creatine Kinase - metabolism
Heart Arrest - complications
Heart Arrest - therapy
Humans
Hypoxia, Brain - enzymology
Isoenzymes
Middle Aged
Prognosis
Resuscitation
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Summary:In patients resuscitated from out-of-hospital cardiac arrest, neurologic outcome was compared with creatine kinase isoenzyme BB activity (CKBB) in cerebrospinal fluid (CSF) in 20 patients and in serum in 52 patients. CSF CKBB was 2 units per liter or less in patients with complete neurologic recovery but was significantly elevated in patients without neurologic recovery (mean, 55 units per liter) or with incomplete neurologic recovery (mean, 7 units per liter). Serum CKBB was detected more than 6 hours after cardiac arrest in only 4% of patients with complete neurologic but in all patients without neurologic recovery. These results demonstrate a relationship between CSF and serum CKBB and neurologic outcome after cardiac arrest.
ISSN:0028-3878
DOI:10.1212/wnl.31.4.455