A ‘NAC’ for targeting proteins to the ER

The signal recognition particle (SRP) cotranslationally targets a large and diverse portion of the nascent proteome to the endoplasmic reticulum (ER). A recent study by Jomaa et al. reveals an unexpected function for the ribosome-bound nascent chain-associated complex (NAC) in sensing ER-targeting s...

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Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 47; no. 9; pp. 730 - 731
Main Authors Coelho, João P.L., Shao, Sichen
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2022
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Summary:The signal recognition particle (SRP) cotranslationally targets a large and diverse portion of the nascent proteome to the endoplasmic reticulum (ER). A recent study by Jomaa et al. reveals an unexpected function for the ribosome-bound nascent chain-associated complex (NAC) in sensing ER-targeting signals and recruiting SRP to the appropriate ribosomes for high-fidelity targeting.
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ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2022.04.007