Applications of covering principle to clinical trials with multiple objectives

A novel covering principle was recently proposed to address the multiplicity issue in the multiple hypotheses testing with a hierarchical structure. In this article, a sieve method is proposed to decompose the family of hypotheses into subfamilies. A Shiny web app in R is developed which makes it ea...

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Bibliographic Details
Published inCommunications in statistics. Simulation and computation Vol. 52; no. 6; pp. 2752 - 2764
Main Authors Zhou, Hong, Li, Huajiang
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 03.06.2023
Taylor & Francis Ltd
Subjects
Applications programs
Closed testing principle
Covering principle
Dominance relation
Familywise error rate
Gate-keeping
Graphical approach
Hypotheses
Multiple testing
Principles
Shiny web app
Smartphones
Test procedures
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Summary:A novel covering principle was recently proposed to address the multiplicity issue in the multiple hypotheses testing with a hierarchical structure. In this article, a sieve method is proposed to decompose the family of hypotheses into subfamilies. A Shiny web app in R is developed which makes it easier for users to build the objective-tailored multiple testing procedure based on the covering principle by a smart phone or a tablet with a web browser. The proposed methods are applied to two real clinical trials, demonstrating the flexibility and greater power than the popular gate-keeping method.
ISSN:0361-0918
1532-4141
DOI:10.1080/03610918.2021.1915334