Steady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory

A set of matrix equations based on the Sensitivity Theory is derived that allows the expression of the global control properties of a pathway as a function of its local properties (and vice versa) by a single matrix inversion. The matrix of the local properties is built up from: (1) the experimental...

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Bibliographic Details
Published inJournal of theoretical biology Vol. 178; no. 1; pp. 1 - 6
Main Authors Cascante, Marta, Puigjaner, Joaquim, Kholodenko, Boris
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 07.01.1996
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Summary:A set of matrix equations based on the Sensitivity Theory is derived that allows the expression of the global control properties of a pathway as a function of its local properties (and vice versa) by a single matrix inversion. The matrix of the local properties is built up from: (1) the experimentally determined coefficients, (2) a link matrix (which corresponds to the moiety-conservation relationships) and (3) the matrix reflecting the structural properties of the pathway.
ISSN:0022-5193
1095-8541
DOI:10.1006/jtbi.1996.0001