New ent-kaurane-type diterpenoid with cytotoxic activity from Croton mekongensis

A new ent-kaurane-type diterpenoid, crotonmekongenin A (1) together with two known compounds, epifriedelanol (2) and sitosterol glucoside (3) from the leaves and twigs of Croton mekongensis were isolated. The structure of these compounds was determined by spectroscopic analysis. The structure of the...

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Published inJournal of asian natural products research Vol. 23; no. 10; pp. 1001 - 1008
Main Authors Udomthawee, Kodchaniphar, Chainok, Kittipong, Jiajaroen, Suwadee, Nuntasaen, Narong, Pompimon, Wilart
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 03.10.2021
Taylor & Francis Ltd
Subjects
Cell lines
Croton mekongensis
Crystallography
Cytotoxicity
Diterpenes
diterpenoid
Euphorbiaceae
Spectroscopic analysis
Toxicity testing
X-ray crystallography
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Summary:A new ent-kaurane-type diterpenoid, crotonmekongenin A (1) together with two known compounds, epifriedelanol (2) and sitosterol glucoside (3) from the leaves and twigs of Croton mekongensis were isolated. The structure of these compounds was determined by spectroscopic analysis. The structure of the new ent-kaurane-type diterpenoid (1) was elucidated using spectroscopic technique and X-ray crystallography analysis. Moreover, the cytotoxicity of all extract and isolated compounds was tested for cytotoxicity against KKU-M213, FaDu, HT-29, MDA-MB-231, A-549, SH-SY5Y, and CL cell lines. Compound 1 showed significant cytotoxic activity (ED 50 ) on FaDu (0.48 µg/ml), HT-29 (0.63 µg/ml), and SH-SY5Y (0.45 µg/ml).
Bibliography:ObjectType-Article-1
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ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1815714