Novel cyclization of bis-Boc-guanidines: expeditive traceless synthesis of 1,3,5-oxadiazinones under microwave conditions
A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones b...
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| Published in | Chemical communications (Cambridge, England) Vol. 46; no. 48; pp. 9170 - 9172 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Royal Soc Chemistry
28.12.2010
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| Abstract | A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones by a traceless synthesis. |
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| AbstractList | A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones by a traceless synthesis. |
| Author | Yellol, Gorakh S. Chung, Tsai-Wen Sun, Chung-Ming |
| Author_xml | – sequence: 1 givenname: Gorakh S. surname: Yellol fullname: Yellol, Gorakh S. organization: Natl Chiao Tung Univ, Dept Appl Chem, Lab Combinatorial Drug Discovery, Hsinchu 30010, Taiwan – sequence: 2 givenname: Tsai-Wen surname: Chung fullname: Chung, Tsai-Wen organization: Natl Chiao Tung Univ, Dept Appl Chem, Lab Combinatorial Drug Discovery, Hsinchu 30010, Taiwan – sequence: 3 givenname: Chung-Ming surname: Sun fullname: Sun, Chung-Ming email: cmsun@mail.nctu.edu.tw organization: Natl Chiao Tung Univ, Dept Appl Chem, Lab Combinatorial Drug Discovery, Hsinchu 30010, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21042632$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s11030_011_9350_1 crossref_primary_10_1021_acscombsci_7b00052 crossref_primary_10_1021_co200188g crossref_primary_10_1002_asia_201000913 crossref_primary_10_1021_jo401364s crossref_primary_10_1016_j_tetlet_2011_03_046 crossref_primary_10_1007_s11030_013_9460_z crossref_primary_10_1016_j_tetlet_2012_05_074 crossref_primary_10_1039_c0ob01126f crossref_primary_10_1002_asia_201100277 crossref_primary_10_1039_c1nj20153k crossref_primary_10_1016_j_tet_2011_06_068 crossref_primary_10_1021_ol201985p crossref_primary_10_1021_co400010y crossref_primary_10_1007_s11030_013_9433_2 crossref_primary_10_1002_adsc_201100640 |
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| SubjectTerms | Amines Azirines - chemistry Chemistry Chemistry, Multidisciplinary Cyclization Dihydropyridines - chemistry Guanidines - chemistry Microwaves Physical Sciences Polyethylene Glycols Science & Technology |
| Title | Novel cyclization of bis-Boc-guanidines: expeditive traceless synthesis of 1,3,5-oxadiazinones under microwave conditions |
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