Novel cyclization of bis-Boc-guanidines: expeditive traceless synthesis of 1,3,5-oxadiazinones under microwave conditions

A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones b...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 46; no. 48; pp. 9170 - 9172
Main Authors Yellol, Gorakh S., Chung, Tsai-Wen, Sun, Chung-Ming
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.12.2010
Subjects
Amines
Azirines - chemistry
Chemistry
Chemistry, Multidisciplinary
Cyclization
Dihydropyridines - chemistry
Guanidines - chemistry
Microwaves
Physical Sciences
Polyethylene Glycols
Science & Technology
CHIRAL AUXILIARIES
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Summary:A novel intramolecular cyclization was discovered during the reaction of soluble polymer supported bis-Boc-guanidines with amines under microwave irradiation, leading to an oxadiazinone skeleton. The cyclized polymer conjugates have been further utilized to generate substituted 1,3,5-oxadiazinones by a traceless synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc03519j