Surface-tethered protein switches

Protein switches are engineered fusion proteins with an input domain that recognizes and responds to an input signal and an output domain whose function is regulated by the state of the input domain. Here we demonstrate a fully functional surface tethered protein switch that offers a potential route...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 12; pp. 3398 - 3400
Main Authors Zayats, Maya, Kanwar, Manu, Ostermeier, Marc, Searson, Peter C
Format Journal Article
LanguageEnglish
Published England 28.03.2011
Subjects
Allosteric Regulation
beta-Lactamases - chemistry
beta-Lactamases - metabolism
Biosensing Techniques
Gold - chemistry
Immobilized Proteins - chemistry
Immobilized Proteins - genetics
Immobilized Proteins - metabolism
Maltose-Binding Proteins - chemistry
Maltose-Binding Proteins - metabolism
Protein Engineering
Protein Structure, Tertiary
Surface Properties
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Summary:Protein switches are engineered fusion proteins with an input domain that recognizes and responds to an input signal and an output domain whose function is regulated by the state of the input domain. Here we demonstrate a fully functional surface tethered protein switch that offers a potential route to a universal biosensing platform.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc10146c