Genetic counselling in psoriasis: empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands

• Published in: British journal of dermatology (1951) Vol. 137; no. 6; pp. 939 - 942
• Main Authors: SWANBECK, G., INEROT, A., MARTINSSON, T., ENERBÄCK, C., ENLUND, F., SAMUELSSON, L., YHR, M., WAHLSTRÖM, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.1997; Blackwell
• Subjects: Adolescent; Adult; Age Factors; Aged; Biological and medical sciences; Child; Child, Preschool; Dermatology; Family Characteristics; Genetic Counseling; Humans; Infant; Medical sciences; Middle Aged; Pedigree; Psoriasis - genetics; Psoriasis. Parapsoriasis. Lichen; Risk Assessment; Human; Skin disease; Genetic character; Psoriasis; Epidemiology; Transmission
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1046/j.1365-2133.1997.19892070.x

Summary The risk of getting psoriasis dependent on the occurence of psoriasis in the family has been determined empirically. Altogether 3717 families with one or both parents who had psoriasis have been analysed with regard to the number of children with or without psoriasis. The lifetime risk of getting psoriasis if no parent, one parent or both parents have psoriasis is 0.04, 0.28 and 0.65, respectively. If there is already one affected child in the family, the corresponding risks are 0.24, 0.51 and 0.83, respectively. The risk of getting psoriasis before the age of 32 years is dependent on the age‐of‐onset of psoriasis in one affected parent.