Metabolism of p-tert.-butyltoluene in the rat and guinea pig

The metabolism of p-tert.-butyltoluene (TBT) was studied in the rat and guinea pig. Both the methyl and the tert.-butyl group were oxidized to alcohol and carboxylic acid derivatives in these species. The major urinary metabolites in rats were p-tert.-butylbenzoic acid and its alcohol derivative 2-(...

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Bibliographic Details
Published inActa pharmacologica et toxicologica Vol. 53; no. 1; p. 57
Main Authors Walde, A, Scheline, R R
Format Journal Article
LanguageEnglish
Published Denmark 01.07.1983
Subjects
Animals
Biotransformation
Gas Chromatography-Mass Spectrometry
Guinea Pigs
Male
Oxidation-Reduction
Rats
Rats, Inbred Strains
Solvents - metabolism
Solvents - urine
Toluene - analogs & derivatives
Toluene - metabolism
Toluene - urine
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Summary:The metabolism of p-tert.-butyltoluene (TBT) was studied in the rat and guinea pig. Both the methyl and the tert.-butyl group were oxidized to alcohol and carboxylic acid derivatives in these species. The major urinary metabolites in rats were p-tert.-butylbenzoic acid and its alcohol derivative 2-(p-carboxyphenyl)-2-methylpropan-1-ol whereas p-tert.-butylbenzoylglycine was the most prominent metabolite in guinea pig urine. No significant differences in metabolism were found when TBT was given intragastrically or by inhalation. The intragastric administration of 14C-TBT to rats showed that the bulk of the excretion of radioactivity occurred within three days. A recovery of 83% was achieved and the ratio of urinary/faecal radioactivity was roughly 3.5:1.
ISSN:0001-6683
DOI:10.1111/j.1600-0773.1983.tb01868.x