Interaction of brain and intracardiac levels of rhythmogenesis hierarchical system at heart rhythm formation

A single-stage bilateral conduction blockade of the vagus nerves (functional denervation) by constant anodal current was carried out in 13 dogs which are under anesthesia and 3-5 days after operation in chronic experiments. In anesthetized animals, "functional denervation" led to accelerat...

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Published inJournal of integrative neuroscience Vol. 7; no. 4; p. 457
Main Authors Pokrovskii, Vladimir M, Abushkevich, Valery G, Gurbich, Dmitriy V, Klykova, Mariya S, Nechepurenko, Anatoliy A
Format Journal Article
LanguageEnglish
Published England 01.12.2008
Subjects
Animals
Autonomic Pathways - physiology
Biological Clocks - physiology
Brain - physiology
Dogs
Electric Stimulation
Heart - innervation
Heart - physiology
Heart Rate - physiology
Periodicity
Reaction Time - physiology
Sinoatrial Node - physiology
Time Factors
Vagus Nerve - physiology
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Summary:A single-stage bilateral conduction blockade of the vagus nerves (functional denervation) by constant anodal current was carried out in 13 dogs which are under anesthesia and 3-5 days after operation in chronic experiments. In anesthetized animals, "functional denervation" led to acceleration of the heart rhythm from 102.4+/-3.2 bmp to 123.8+/-4.4 bmp. In chronic dogs "functional denervation" led to transient stoppage of the heart--a preautomatic pause with duration of 2.7+/-0.2 sec. The heartbeats recommenced with the frequency of 89.0+/-3.4 bmp versus an initial rhythm of 118+/-1.5 bpm, i.e., a rhythm deceleration took place. We conclude that in a whole organism the heart rhythm pacemaker is determined by a brain level of the hierarchical system of rhythmogenesis, while the sinoatrial node plays the role of a latent pacemaker.
ISSN:0219-6352
DOI:10.1142/S0219635208001988