An adult case of histiocytosis X with a vulvar ulcer and multiple bone lesions

A 62-year-old female with histiocytosis X presented with a vulvar ulcer. Multiple osteolytic lesions were later detected. Histological examination of the ulcerated skin showed diffuse proliferation of histiocytic cells with folded nuclei and pale eosinophilic cytoplasm. Immunohistochemistry revealed...

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Bibliographic Details
Published inJournal of dermatology Vol. 21; no. 4; p. 259
Main Authors Takata, M, Taniguchi, A, Imai, T, Hirone, T, Nonomura, A, Fukui, Y
Format Journal Article
LanguageEnglish
Published England 01.04.1994
Subjects
Female
Histiocytosis, Langerhans-Cell - complications
Histiocytosis, Langerhans-Cell - pathology
Humans
Immunohistochemistry
Middle Aged
Osteolysis
Ulcer - complications
Ulcer - pathology
Vulvar Diseases - complications
Vulvar Diseases - pathology
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Summary:A 62-year-old female with histiocytosis X presented with a vulvar ulcer. Multiple osteolytic lesions were later detected. Histological examination of the ulcerated skin showed diffuse proliferation of histiocytic cells with folded nuclei and pale eosinophilic cytoplasm. Immunohistochemistry revealed S100 protein and vimentin as well as CD1a, CD4, and HLA-DR antigens in the proliferating cells. Electron microscopy demonstrated Birbeck granules in the cytoplasm of the cells. The patient was successfully treated by complete surgical excision of the ulcer followed by radiotherapy for recurrent vulvar erythema.
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1994.tb01733.x