Comparative study of Ki-67 immunostaining and nuclear DNA content in histiofibrous tumors

A comparative assessment was made of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma. The study was comprised of an immunohistochemical investigation using the Ki-67 monoclonal antibody and a quantitative analysis of cell nuclear DNA using flow cytometry. It was f...

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Bibliographic Details
Published inJournal of dermatology Vol. 19; no. 1; p. 12
Main Authors Ooe, M, Nogita, T, Kawashima, M
Format Journal Article
LanguageEnglish
Published England 01.01.1992
Subjects
Adult
Diagnosis, Differential
DNA, Neoplasm - analysis
Female
Fibroma - diagnosis
Fibrosarcoma - diagnosis
Fibrosarcoma - genetics
Histiocytoma, Benign Fibrous - diagnosis
Humans
Immunohistochemistry
Ki-67 Antigen
Male
Middle Aged
Nuclear Proteins
Skin Neoplasms - diagnosis
Skin Neoplasms - genetics
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Summary:A comparative assessment was made of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma. The study was comprised of an immunohistochemical investigation using the Ki-67 monoclonal antibody and a quantitative analysis of cell nuclear DNA using flow cytometry. It was found that the index of Ki-67 monoclonal antibody labeling, the histogram pattern, and DNA index correlated with clinical malignancy, suggesting the usefulness of these indices for differential diagnosis and evaluation of prognosis.
ISSN:0385-2407
DOI:10.1111/j.1346-8138.1992.tb03173.x