Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl₂]₂ with Chiral Amino Alcohol Ligands

• Published in: Catalysis letters Vol. 138; no. 3-4; pp. 231 - 238
• Main Authors: Deshpande, Sudhindra H, Kelkar, Ashutosh A, Gonnade, Rajesh G, Shingote, Savita K, Chaudhari, Raghunath V
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.09.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Acids; Alcohol; Alcohols; Amino alcohol ligand; Asymmetric transfer hydrogenation; Asymmetry; Catalysis; Chemistry; Chemistry and Materials Science; Conversion; Exact sciences and technology; General and physical chemistry; Hydrogenation; Industrial Chemistry/Chemical Engineering; Ketones; Lactic acid; Ligands; Organometallic Chemistry; Physical Chemistry; Ru catalyst; Synthesis; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; Ru catalyst; Amino alcohol ligand; Ketones; Asymmetric transfer hydrogenation; Ligand effect; Catalytic reaction; Aminoalcohol; Hydrocarbon; Enantioselectivity; Organic ligand; Alcohol; Asymmetric catalysis; Conversion; Ketone; Hydrogenation; Alkyl; Cymene; Complexes Mixed; Benzenic compound; Chloro complex; Ru catalysts; Lactic acid; Secondary alcohol; Catalyst
• ISSN: 1011-372X; 1572-879X
• DOI: 10.1007/s10562-010-0408-y

Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). Graphical Abstract Asymmetric transfer hydrogenation of ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and β-amino alcohols synthesized from (S)-(−)-lactic acid and Mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). [graphic removed]