NKG2 receptor-mediated regulation of effector CTL functions in the human tissue microenvironment

NKG2 receptors and their ligands play an essential role in the control of CTL activation in the tissue microenvironment. We discuss the regulation of NKG2 receptor expression by CTL and how uncontrolled activation of NKG2 receptors can lead to organ-specific autoimmune and inflammatory disorders.

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Bibliographic Details
Published inCurrent topics in microbiology and immunology Vol. 298; p. 139
Main Authors Jabri, B, Meresse, B
Format Journal Article
LanguageEnglish
Published Germany 2006
Subjects
Autoimmunity
Humans
In Vitro Techniques
Interleukin-15 - metabolism
Killer Cells, Natural - immunology
Ligands
Models, Immunological
NK Cell Lectin-Like Receptor Subfamily C
NK Cell Lectin-Like Receptor Subfamily D - metabolism
Receptors, Antigen, T-Cell - metabolism
Receptors, Immunologic - metabolism
Receptors, Natural Killer Cell
Signal Transduction - immunology
T-Lymphocytes, Cytotoxic - immunology
Tissue Distribution
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Summary:NKG2 receptors and their ligands play an essential role in the control of CTL activation in the tissue microenvironment. We discuss the regulation of NKG2 receptor expression by CTL and how uncontrolled activation of NKG2 receptors can lead to organ-specific autoimmune and inflammatory disorders.
ISSN:0070-217X
DOI:10.1007/3-540-27743-9_7