Purine metabolism in the bloodstream forms of trypanosoma gambiense and Trypanosoma rhodesiense

Bloodstream forms of Trypanosoma brucie gambiense and Trypanosoma brucei rhodesiense are incapable of de novo purine synthesis. Purine bases are converted directly to ribonucleotides and with the exception of guanine, are stable. Guanine is incorporated directly into ribonucleotides and also deamina...

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Published inBiochimica et biophysica acta. General subjects Vol. 719; no. 2; pp. 223 - 231
Main Authors Fish, Wallace R., Looker, Douglas L., Joseph Marr, J., Berens, Randolph L.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.1982
Subjects
Bloodstream form
Parasite
Purine metabolism
Trypanosome
Parasite
Bloodstream form
Purine metabolism
Trypanosome
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Summary:Bloodstream forms of Trypanosoma brucie gambiense and Trypanosoma brucei rhodesiense are incapable of de novo purine synthesis. Purine bases are converted directly to ribonucleotides and with the exception of guanine, are stable. Guanine is incorporated directly into ribonucleotides and also deaminated to xanthine. Purine ribonucleosides are hydrolyzed rapidly; these reactions may limit their incorporation since purine bases label the nucleotide pools more efficiently than do ribonucleosides. The apparent order of salvage efficiency for ribonucleosides is adenosine>inosine>guanosine>xanthosine for both organisms. T. b. gambiense salvages purine bases in the same order, while T. b. rhodesiense salvages purine bases in the order hypoxanthine>adenine>guanine>xanthine.
ISSN:0304-4165
1872-8006
DOI:10.1016/0304-4165(82)90092-7