Electrospun nanofibers in drug delivery: recent developments and perspectives

In this review article, some key challenges in drug delivery are first introduced and methods that have been applied in attempts to solve them enumerated. Particularly intractable problems are highlighted: these include issues of solubility, targeting and drug degradation. The technique of electrosp...

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Bibliographic Details
Published inTherapeutic delivery Vol. 3; no. 4; p. 515
Main Authors Williams, Gareth R, Chatterton, Nicholas P, Nazir, Tahir, Yu, Deng-Guang, Zhu, Li-Min, Branford-White, Christopher J
Format Journal Article
LanguageEnglish
Published England 01.04.2012
Subjects
Animals
Biological Transport
Chemistry, Pharmaceutical - trends
Drug Carriers
Drug Compounding - trends
Drug Delivery Systems - trends
Drug Stability
Gene Transfer Techniques - trends
Humans
Nanofibers
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Solubility
Technology, Pharmaceutical - trends
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Summary:In this review article, some key challenges in drug delivery are first introduced and methods that have been applied in attempts to solve them enumerated. Particularly intractable problems are highlighted: these include issues of solubility, targeting and drug degradation. The technique of electrospinning is subsequently introduced, and the influence of processing parameters on the fibers produced discussed. The potential of electrospun nanofibers in drug delivery is then explored, with examples given from the recent literature to illustrate how fibers can be used to overcome hurdles in drug solubility, degradation and targeting. Future perspectives and challenges are also considered.
ISSN:2041-5990
DOI:10.4155/tde.12.17