Polyanion inhibitors of human immunodeficiency virus. Part IV. - polymerized anionic surfactants: Influence of the density and distribution of anionic groups on the antiviral activity

The synthesis of a series of new polyamions, via γ-polymerization, of ω-unsaturated multi-charged anionic surfactants, has been realized. These polyanions were evaluated for their activity against HIV-1. All tested compounds proved active without presenting toxicity to the host cells (CEM-4 or MT-4)...

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Published inBioorganic & medicinal chemistry letters Vol. 6; no. 4; pp. 397 - 402
Main Authors Leydet, Alain, Barthélémy, Philippe, Boyer, Bernard, Lamaty, Gérard, Roque, Jean-Pierre, Witvrouw, Myriam, Clercq, Erik De
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.02.1996
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Summary:The synthesis of a series of new polyamions, via γ-polymerization, of ω-unsaturated multi-charged anionic surfactants, has been realized. These polyanions were evaluated for their activity against HIV-1. All tested compounds proved active without presenting toxicity to the host cells (CEM-4 or MT-4). Polyanions have been prepared from ω-unsaturated multicharged anionic surfactants to evaluate the influence of the charge density and charge distribution upon their anti-HIV activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00042-X