Continuous production of L-malic acid by immobilized cells

l-Malic acid is used extensively in the pharmaceutical industry and as a food additive. It is now produced on an industrial scale by the enzymatic conversion of fumaric acid using immobilized cells of Brevibacterium flavum. Recent improvements to this system, especially the use of x-carrageenan supp...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 1; no. 1; pp. 9 - 11
Main Authors Chibata, Ichiro, Tosa, Tetsuya, Takata, Isao
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.03.1983
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Summary:l-Malic acid is used extensively in the pharmaceutical industry and as a food additive. It is now produced on an industrial scale by the enzymatic conversion of fumaric acid using immobilized cells of Brevibacterium flavum. Recent improvements to this system, especially the use of x-carrageenan supports, have resulted in a continuous process capable of yielding 30 tonnes of l-malic acid per month.
ISSN:0167-7799
1879-3096
DOI:10.1016/0167-7799(83)90019-7