A role for upstream binding factor in organizing ribosomal gene chromatin

• Published in: Biochemical Society Symposia no. 73; p. 77
• Main Authors: Wright, Jane E, Mais, Christine, Prieto, José-Luis, McStay, Brian
• Format: Journal Article
• Language: English
• Published: England 2006
• Subjects: Binding Sites - genetics; Chromatin - genetics; Chromatin - metabolism; DNA, Ribosomal - genetics; DNA, Ribosomal - metabolism; Humans; Nucleolus Organizer Region - genetics; Nucleolus Organizer Region - metabolism; Pol1 Transcription Initiation Complex Proteins - genetics; Pol1 Transcription Initiation Complex Proteins - metabolism; Protein Binding; Ribosomes - genetics; Ribosomes - metabolism

Human ribosomal genes are located in NORs (nucleolar organizer regions) on the short arms of acrocentric chromosomes. During metaphase, previously active NORs appear as prominent chromosomal features termed secondary constrictions, which are achromatic in chromosome banding and positive in silver st...