Soft cluster-induced desorption/ionization mass spectrometry: How soft is soft?

Desorption/ionization induced by neutral clusters (DINeC) is used as an ultrasoft desorption/ionization method for the analysis of fragile biomolecules by means of mass spectrometry (MS). As a test molecule, the glycopeptide vancomycin was measured with DINeC-MS, and resulting mass spectra were comp...

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Bibliographic Details
Published inBiointerphases Vol. 15; no. 2; p. 021001
Main Authors Portz, André, Bomhardt, Karolin, Rohnke, Marcus, Schneider, Pascal, Asperger, Arndt, Gebhardt, Christoph R, Dürr, Michael
Format Journal Article
LanguageEnglish
Published United States 01.03.2020
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Summary:Desorption/ionization induced by neutral clusters (DINeC) is used as an ultrasoft desorption/ionization method for the analysis of fragile biomolecules by means of mass spectrometry (MS). As a test molecule, the glycopeptide vancomycin was measured with DINeC-MS, and resulting mass spectra were compared to the results obtained with electrospray ionization (ESI), matrix assisted laser desorption ionization, and time-of-flight secondary ion MS. Of the desorption-based techniques, DINeC spectra show the lowest abundance of fragments comparable to ESI spectra. The soft desorption nature of DINeC was further demonstrated when applied to MS analysis of teicoplanin.
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ISSN:1934-8630
1559-4106
DOI:10.1116/6.0000046