Dystrophic Chicken Muscle: Altered Synaptic Acetylcholinesterase

Individual motor endplates in the skeletal muscles of chickens genetically homozygous for muscular dystrophy have been compared with those in normal chickens. Measurements were made there, by specific autoradiographic techniques, of the numbers of total cholinesterase-like molecules and of acetylcho...

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Published inScience (American Association for the Advancement of Science) Vol. 180; no. 4084; pp. 406 - 408
Main Authors Jedrzejczyk, J., Wieckowski, J., Rymaszewska, T., Barnard, E. A.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 27.04.1973
Subjects
Acetylcholinesterase - analysis
Animals
Autoradiography
Cell lines
Cell mediated immunity
Chickens
Cholinesterases - analysis
Choroid plexus
Grants
Homozygote
Muscles
Muscular dystrophies
Muscular Dystrophy, Animal - enzymology
Muscular Dystrophy, Animal - genetics
Neuromuscular Junction - enzymology
Pain
Phosphorus Isotopes
Systemic lupus erythematosus
T lymphocytes
Tritium
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Summary:Individual motor endplates in the skeletal muscles of chickens genetically homozygous for muscular dystrophy have been compared with those in normal chickens. Measurements were made there, by specific autoradiographic techniques, of the numbers of total cholinesterase-like molecules and of acetylcholinesterase molecules. The acetylcholinesterase is distinctly decreased at the endplates in dystrophic muscles. The various data available on these muscles are compatible with the concept that a neural factor which determines the synaptic acetylcholinesterase, along with a number of other characters in the muscle cell, is defective in this disorder.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.180.4084.406