Phosgene: a practitioner's viewpoint

Clinical experience with five patients exposed to phosgene is described. The treatment of phosgene poisoning was focused upon the presenting problem, pulmonary edema. Arterial hypoxemia was treated with a face mask with 10 cm CPAP with the FiO2 adjusted as needed or with a volume ventilator with con...

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Bibliographic Details
Published inToxicology and industrial health Vol. 1; no. 2; p. 81
Main Author Wells, B A
Format Journal Article
LanguageEnglish
Published England 01.10.1985
Subjects
Acid-Base Imbalance - drug therapy
Acid-Base Imbalance - etiology
Adult
Bicarbonates - therapeutic use
Combined Modality Therapy
Furosemide - therapeutic use
Humans
Hypoxia - etiology
Hypoxia - therapy
Laryngeal Edema - chemically induced
Male
Occupational Diseases - chemically induced
Occupational Diseases - therapy
Oxygen Inhalation Therapy
Phosgene - poisoning
Pulmonary Edema - chemically induced
Pulmonary Edema - complications
Pulmonary Edema - therapy
Sodium - therapeutic use
Sodium Bicarbonate
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Summary:Clinical experience with five patients exposed to phosgene is described. The treatment of phosgene poisoning was focused upon the presenting problem, pulmonary edema. Arterial hypoxemia was treated with a face mask with 10 cm CPAP with the FiO2 adjusted as needed or with a volume ventilator with controlled ventilation. Ventilation was controlled to reduce the work of breathing. Metabolic acidosis was treated with NaCHO3 to produce a normal pH. A vigorous program of diuresis was used to treat the pulmonary edema. Lasix was administered to produce a negative fluid balance while maintaining a good urinary output. The negative fluid balance correlated well with reduced oxygen requirements.
ISSN:0748-2337
DOI:10.1177/074823378500100209