Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements

• Published in: Journal of pediatric hematology/oncology Vol. 21; no. 2; p. 142
• Main Authors: Papakonstantinou, O, Kostaridou, S, Maris, T, Gouliamos, A, Premetis, E, Kouloulias, V, Nakopoulou, L, Kattamis, C
• Format: Journal Article
• Language: English
• Published: United States 01.03.1999
• Subjects: Adolescent; Adult; Alanine Transaminase - blood; Biomarkers; Biopsy; Female; Ferritins - blood; Hemophilia A - complications; Hemophilia A - pathology; Hemophilia A - therapy; Hepatitis C, Chronic - enzymology; Hepatitis C, Chronic - etiology; Hepatitis C, Chronic - pathology; Humans; Iron Overload - diagnosis; Iron Overload - etiology; Iron Overload - metabolism; Iron Overload - pathology; Liver - chemistry; Liver - pathology; Liver Cirrhosis - complications; Liver Cirrhosis - pathology; Magnetic Resonance Imaging; Male; Sensitivity and Specificity; Thalassemia - complications; Thalassemia - pathology; Thalassemia - therapy; Transfusion Reaction
• ISSN: 1077-4114
• DOI: 10.1097/00043426-199903000-00011

Measurement of liver T2 values seems to be an accurate and sensitive magnetic resonance imaging (MRI) method for the quantification of liver hemosiderosis in multiple transfused patients with thalassemia. Because many of these patients have coexistent chronic hepatitis C virus (HCV) infection, the effect of inflammatory changes on liver T2 values was assessed. Liver MRI studies of 35 HCV+ and 17 HCV- patients with beta-thalassemia, 9 HCV+ patients without thalassemia, and 10 healthy controls of the same age range (13 to 32 years) were reviewed. Iron status was assessed by serum ferritin in all patients, and determination of liver iron concentration (LIC) was available in 16 HCV+ patients with thalassemia. Histologic activity index (HAI) and grades of siderosis were evaluated in all HCV+ patients with thalassemia. Patients with thalassemia had significantly lower T2 values (P < 0.0001) than subjects without thalassemia, whereas no difference existed between HCV+ patients without thalassemia and healthy controls. In HCV+ patients, LIC correlated more nearly with T2 values (r = 0.93) than with serum ferritin (r = 0.73). T2 values were not influenced by HAI score or fibrosis. Liver T2 values were found to be more accurate than serum ferritin in predicting liver iron overload and were not influenced by the presence of chronic hepatitis C. Therefore, MRI could serve as a noninvasive alternative to liver biopsy for the quantification of hemosiderosis in HCV+ patients with thalassemia.