Polar cell fate stimulates Wolbachia intracellular growth

Bacteria are crucial partners in the development and evolution of vertebrates and invertebrates. A large fraction of insects harbor , bacterial endosymbionts that manipulate host reproduction to favor their spreading. Because they are maternally inherited, are under selective pressure to reach the f...

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Published inDevelopment (Cambridge) Vol. 145; no. 6; p. dev158097
Main Authors Kamath, Ajit D, Deehan, Mark A, Frydman, Horacio M
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 15.03.2018
Subjects
Animals
Arthropods
Bacteria
Cell fate
Developmental stages
Drosophila
Drosophila - microbiology
Endosymbionts
Female
Fluorescent Antibody Technique
In Situ Hybridization, Fluorescence
Insects
Intracellular
Morphogenesis
Oogenesis
Oogenesis - physiology
Ovary - cytology
Ovary - microbiology
Pattern formation
Polar Bodies - microbiology
Somatic cells
Stem cells
Symbiosis - physiology
Tropism
Viral Tropism - physiology
Wolbachia
Wolbachia - pathogenicity
Polar cell
Drosophila oogenesis
Endosymbiont
Wolbachia
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Summary:Bacteria are crucial partners in the development and evolution of vertebrates and invertebrates. A large fraction of insects harbor , bacterial endosymbionts that manipulate host reproduction to favor their spreading. Because they are maternally inherited, are under selective pressure to reach the female germline and infect the offspring. However, infection is not limited to the germline. Somatic cell types, including stem cell niches, have higher loads compared with the surrounding tissue. Here, we show a novel tropism to polar cells (PCs), specialized somatic cells in the ovary. During oogenesis, all stages of PC development are easily visualized, facilitating the investigation of the kinetics of intracellular growth. accumulation is triggered by particular events of PC morphogenesis, including differentiation from progenitors and between stages 8 and 9 of oogenesis. Moreover, induction of ectopic PC fate is sufficient to promote accumulation. We found that PC tropism is evolutionarily conserved across most species, but not in mosquitos. These findings highlight the coordination of endosymbiont tropism with host development and cell differentiation.
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ISSN:0950-1991
1477-9129
DOI:10.1242/DEV.158097